Trilostane 10mg Tablets for Dogs – 100 Tablets

GENERAL INFORMATION

What is Trilostane used for?

Trilostane tablets 10mg are indicated for the treatment of Pituitary-dependent hyperadrenocorticism (Cushing's disease) in dogs and Adrenal-dependent hyperadrenocorticism in dogs. Trilostane tablets 10mg helps control the adrenal gland's excessive production of cortisol, a hormone released into the bloodstream during times of stress.

How does Trilostane work?

Trilostane tablets 10mg works by blocking the production of cortisol in the adrenal glands. Cortisol is a hormone that helps regulate stress responses, metabolism, blood pressure, and immune function.

In dogs with Cushing's disease (hyperadrenocorticism), the adrenal glands produce excessive amounts of cortisol. Trilostane tablets 10mg inhibits an enzyme involved in cortisol synthesis, which reduces cortisol production and helps restore hormone levels closer to normal.

As cortisol levels decrease, clinical signs of Cushing's disease may improve, including:

• Excessive thirst and urination
• Increased appetite
• Panting
• Hair loss
• Pot-bellied appearance
• Lethargy and weakness

Trilostane tablets 10mg controls the disease but does not cure it. Most dogs require lifelong treatment and regular veterinary monitoring to ensure cortisol levels remain within a safe range.

What does Trilostane contain?

Trilostane tablets 10mg contain Trilostane, and other excipients.

What are the side effects of Trilostane?

The most commonly reported adverse reactions include:

• Reduced appetite
• Vomiting
• Lethargy
• Dullness
• Diarrheoa
• Weakness

Occasionally, more serious reactions may occur, including:

• Severe depression
• Hemorrhagic diarrhoea
• Collapse
• Hypoadrenocortical crisis
• Adrenal necrosis or rupture

How should Trilostane be taken?

The recommended dose for the treatment of hyperadrenocorticism (Cushing's disease) in dogs is:

1 mg/lb (2.2 to 6.7 mg/kg) once daily

• Start with the lowest possible dose based on the dog's body weight and available tablet strengths.
• The duration of treatment depends on:

• The condition being treated
• The dog's response to the medication
• The development of any adverse effects

Note: Consult your veterinarian for accurate dosage information.

How long should you give Trilostane?

• The duration of treatment depends on:

• The condition being treated
• The dog's response to the medication
• The development of any adverse effects

Missed dose of Trilostane

If you miss a dose of Trilostane tablets 10mg give it as soon as you remember, unless it is time to give the next dose, then skip the missed dose.  Do not give a double dose.

How should Trilostane be stored?

Store in a cool, dry place in the original packaging, protected from sunlight.