Motis (Domperidone 10mg) 21 Tablets/ Pack (Turkish)

General Information

What is Motis used for?

Motis is used to treat nausea and vomiting and help relieve symptoms like bloating, fullness, heartburn and flatulence that cause discomfort when the digestive system is out of rhythm or you have eaten too much. Motis can also be used to relieve symptoms of nausea caused by some medications, such as anti-cancer drugs and medications used for Parkinson’s disease. Another use for Motis is to increase breast milk production, as a side effect of its intended use.

How does Motis work?

Motis contains domperidone, a dopamine antagonist that acts as an antiemetic (prevents nausea and vomiting) and as a gastrokinetic (stimulates gastrointestinal mobility). Nausea and vomiting are triggered when the chemoreceptor trigger zone (CTZ) in the brain is stimulated, and this causes nerve impulses to be sent to area postrema or vomiting centre of the brain, to induce the vomiting reflex. The CTZ can be activated by two mechanisms; either indirectly by transmission of nerve impulses sent to the brain from the stomach when it has been irritated, or directly by chemicals or drugs that are circulating in the blood and stimulate receptors in the brain. Motis works by blocking the action of the chemical messenger dopamine and this stops the transmission of messages from the irritated or upset stomach to the brain, preventing the brain triggering the vomiting response. Motis also blocks the same chemical messengers in the upper digestive system. This relieves dysmobility, which is when food processing slows down causing uncomfortable symptoms. Motis restores the natural rhythm of muscle contraction and relaxation in the stomach, which helps push food through the digestive system and prevents vomiting.

What does Motis contain?

Motis tablets 10mg contain the active ingredient domperidone, an antiemetic used to relieve nausea and vomiting.
Inactive ingredients: lactose, maize starch, microcrystalline cellulose, pregelatinised potato starch, povidone, magnesium stearate, hydrogenated cottonseed oil, sodium lauryl sulfate, hypromellose, and purified water.

Treating nausea and vomiting with Motis

Motis tablets 10mg contain domperidone, a dopamine antagonist that is used as antiemetic (prevents nausea and vomiting) to treat nausea and vomiting caused by a variety of conditions, including, gastrointestinal disorders or medication such as anti-cancer drugs. Motis works by blocking the action of the chemical messenger dopamine in the brain and in the upper intestine, and this prevents vomiting and restores the natural rhythm of the digestive system. The action of Motis helps relieve symptoms of digestive problems including bloating, fullness, heartburn, regurgitation of bile, abdominal pain and flatulence, which can happen when the digestive system is out of rhythm and cause discomfort.

How does Motis help with breastfeeding?

If you are having trouble producing enough breast milk you can use Motis to help with breastfeeding. Domperidone 10mg, the active ingredient of Motis, increases blood levels of the hormone prolactin, which stimulates milk production in a new mother’s breast cells. This is an indirect result of blocking the chemical messenger dopamine, which is also how Motis prevents nausea and vomiting. Motis does pass from the blood into breast milk, however, it is present in small amounts and there is no indication that it will harm the baby. Motis has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production.

Motis for increasing breast milk production

Motis can be used to increase breast milk production as it has been found to increase blood levels of the hormone prolactin, which stimulates milk production in a new mother’s breast cells. This is an indirect result of blocking the chemical messenger dopamine, which is also how Motis prevents nausea and vomiting. Motis does pass from the blood into your breast milk, however, it is present in small amounts and there is no indication that it will harm the baby. Motis has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production.

What are the side effects of Motis?

The most commonly reported side effects when taking Motis include: headache, abdominal cramps and dry mouth. Because Motis does not cross the blood brain barrier it does not cause what are known as extrapyramidal side effects, like convulsion and involuntary muscle actions that can be associated with some dopamine blocking medications. However, for the same reason Motis can increase the production of the hormone prolactin, which stimulates breast milk secretion, and this can cause breast enlargement (gynaecomastia) and temporary stoppage of periods (amenorrhoea). These side effects will stop as soon as you stop taking Motis.

When should Motis not be used?

You should not use Motis if you:

• are allergic to domperidone or any of the other components in Motis
• have an intolerance to lactose, a lactose malabsorption or a genetic disorder leading to accumulation of galactose in the blood (galactosaemia), as lactose is used to coat the tablets
• have a condition where increasing gut motility could be harmful, such as gastrointestinal haemorrhage, mechanical obstruction or a perforation
• have a kidney or liver condition than causes impairment of renal or hepatic function
• have a pituitary tumour that causes over-production of prolactin (prolactinoma)
• are taking another medication that may interact with Motis and prevent one or both drugs working effectively, such as the antifungals ketoconazole, fluconazole or voriconazole, antibiotics containing erythromycin, clarithromycin or telithromycin; amiodarone for rapid heart beat.

How should Motis be taken?

You should take Motis tablets 10mg swallowed whole with a glass of water 15 to 30 minutes before meals. If you are over 16, you can take a tablet three times a day and at bedtime, if necessary.
To increase breastmilk the usual dosage recommended by lactation consultants is up to TWO tablets FOUR times a day.
The dose you take and for how long depends on what you are being treated for and your doctor’s recommendation.

How long should you take Motis?

You should continue to take Motis for as long as recommended by your doctor.

Missed dose of Motis

If you miss a dose of Motis, take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Motis be stored?

You should store your Motis tablets 10mg below 30°C in a cool dry place and protect from light.